2-pyridone derivatives as inhibitors of neutrophile elastase

Details 2-pyridone derivatives as inhibitors of neutrophile elastase 2-pyridone derivatives as inhibitors of neutrophile elastase

C - Chemistry, Metallurgy

07

D

C07D 211/86 (2006.01) A61K 31/4412 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01) C07D 213/64 (2006.01) C07D 213/82 (2006.01) C07D 239/22 (2006.01) C07D 239/557 (2006.01) C07D 241/24 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2504766

There are provided novel compounds of formula (I) wherein R1, R4, R5, G1, G2, X, L, Y1, Y2 and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.

L'invention concerne de nouveaux composés représentés par la formule (I), dans laquelle R¿1?, R¿4?, R¿5?, G¿1?, G¿2?, X, L, Y¿1?, Y¿2? et n sont tels que définis dans la description, des isomères optiques, des racémates et des tautomères de ceux-ci ainsi que des sels pharmaceutiquement acceptables de ceux-ci. L'invention concerne également des procédés de préparation de ces composés, des compositions les contenant ainsi que leur utilisation en thérapie. Ces composés sont des inhibiteurs de l'élastase de neutrophile.

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