2-pyridone derivatives as netrophil elastase inhibitors and...

Details 2-pyridone derivatives as netrophil elastase inhibitors and... 2-pyridone derivatives as netrophil elastase inhibitors and...

C - Chemistry, Metallurgy

07

D

C07D 211/86 (2006.01) A61K 31/4412 (2006.01) A61P 29/00 (2006.01) C07D 241/08 (2006.01)

Patent

CA 2538410

There are provided novel compounds of formula (I), wherein R1, R2, R4, R5, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.

La présente invention concerne de nouveaux composés représentés par la formule (I), dans laquelle R¿1?, R¿2?, R¿4?, R¿5?, G¿1?, G¿2?, L, Y et n sont tels que définis dans les spécifications et, des isomères optiques, des racemates et des tautomères de ceux-ci ainsi que des sels ceux-ci répondant aux normes pharmaceutiques, des processus de préparation de ses composés, des compositions contenant ces composés et leur utilisation dans la thérapie. Ces composés sont des inhibiteurs d'élastase neutrophile.

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