2-pyridylacetic acid derivative, preparation process thereof...

Details 2-pyridylacetic acid derivative, preparation process thereof... 2-pyridylacetic acid derivative, preparation process thereof...

C - Chemistry, Metallurgy

07

D

167/228, 260/291

C07D 213/59 (2006.01) A61K 31/44 (2006.01) C07D 401/12 (2006.01)

Patent

CA 1300153

ABSTRACT OF THE DISCLOSURE A 2-pyridylacetic acid derivative having the formula (I): Image (I) wherein Rl represents an alkyl having 1 to 15 carbon atoms, an alkenyl having 5 to 20 carbon atoms or an aralkyl having 7 to 15 carbon atoms; R2 represents hydrogen, a linear or cyclic alkyl, a nydroxyalkyl group, an alkenyl, an aryl, an aralkyl or a group - (CH2) - A, where n represents an integer of O to 3 and A represents a nitrogen-containing heterocyclic group which may be substituted with an alkyl having 1 to 10 carbon atoms or an aralkyl having 7 to 10 carbon atoms and a pharmacologically acceptable acid addition salt thereof. This compound has both effects of the inhibition of gastric acid and the protection of gastric mucosa, which is low in toxicity. Accordingly, it is useful as a therapeutic agent for peptic ulcer disease. The preparation of this compound is also disclosed.

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