2-pyrrolidinone derivatives substituted at position 4 for...

Details 2-pyrrolidinone derivatives substituted at position 4 for... 2-pyrrolidinone derivatives substituted at position 4 for...

C - Chemistry, Metallurgy

07

D

C07D 207/38 (2006.01) A61K 31/40 (2006.01) C07D 207/267 (2006.01) C07D 209/54 (2006.01)

Patent

CA 2310319

The invention relates to 4-substituted 2-pyrrolidinone derivatives used as a therapeutic active substance. Astonishingly, said compounds were found to be able to lower the level of extracellular glutamate in a substantial manner. Said compounds are suitable for use in prophylaxis and the treatment of a plurality of diseases, especially cerebral apoplexy.

L'invention concerne des dérivés de 2-pyrrolidinone substitués en position 4 s'utilisant comme principe actif thérapeutique. Etonnamment, on a trouvé que ces composés permettent d'abaisser considérablement le niveau de glutamate extracellulaire. Ces composés s'utilisent de ce fait pour assurer la prophylaxie et le traitement d'une pluralité de maladies, y compris en particulier l'apoplexie cérébrale.

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