2 pyrrolidone derivatives as prostanoid agonists

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 207/26 (2006.01) A61K 31/4015 (2006.01) A61P 19/10 (2006.01) C07D 207/273 (2006.01) C07D 207/46 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2451393

This invention relates to 8-aza prostanoid analogs which are generally EP4 receptor agonists and are represented by Formula I:wherein Q, B, X, I, Z, A and R1-R6 are as defined in the description, their synthesis and use for treatment of osteoporosis and increasing bone density.

L'invention se rapporte à des analogues 8-aza prostanoïdes qui sont généralement des agonistes récepteurs EP¿4? et représentés par la formule (I), dans laquelle Q, B, X, I, Z, A et R?1¿-R?6¿ sont tels que définis dans le descriptif, à leur synthèse et à leur utilisation dans le traitement de l'ostéoporose et l'accroissement de la densité osseuse.

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