2-s-benzyl substituted pyrimidines as crth2 antagonists

Details 2-s-benzyl substituted pyrimidines as crth2 antagonists 2-s-benzyl substituted pyrimidines as crth2 antagonists

C - Chemistry, Metallurgy

07

D

C07D 239/47 (2006.01) A61K 31/505 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2700525

Provided herein are 2-S-benzyl pyrimidine compounds having CRTH2 (G-protein- coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity, useful for the prophylaxis and treatment of diseases associated with CRTH2 activity, including the treatment of allergic diseases, eosinophil-related diseases and basophil--related diseases.

L'invention porte sur des composés 2-S-benzyl pyrimidine ayant une activité antagoniste de CRTH2 (récepteur chimio-attractif couplé à la protéine G, exprimé sur des cellules Th2), utile pour la prophylaxie et le traitement de maladies associées à une activité CRTH2, comprenant le traitement de maladies allergiques, de maladies liées aux éosinophiles et de maladies liées aux basophiles.

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