2-saccharinylmethyl and...

Details 2-saccharinylmethyl and... 2-saccharinylmethyl and...

C - Chemistry, Metallurgy

07

F

C07F 9/547 (2006.01) A61K 31/675 (2006.01) C07F 9/6541 (2006.01) C07F 9/6558 (2006.01) C07F 9/6574 (2006.01)

Patent

CA 2085427

D.N. 7467 NOVEL 2-SACCHARINYLMETHYL AND 4,5,6,7- TETRAHYDRO-2-SACCHARINYLMETHYL PHOSPHATES, PHOSPHONATES AND PHOSPHINATES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND COMPOSITIONS AND METHOD OF USE THEREOF ABSTRACT 4-R1-R2-R3-2-Saccharinylmethyl, 4-R4-4-R5-6-R6- 4,5,6,7-tetrahydro-2-saccharinylmethyl and 4,7-C-4,5,6,7- tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates of formulas I, II and IIA respectively herein, useful in the treatment of degenerative diseases, and compositions containing them, methods for using them to treat degenerative diseases, and processes for their preparation by reaction of the corresponding 2-halomethylsaccharins with a phosphate, phosphonate or phosphinic acid of formula III herein in the presence of an acid-acceptor. FWS:BE

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