2-saccharinylmethyl phosphates, phosphonates and...

Details 2-saccharinylmethyl phosphates, phosphonates and... 2-saccharinylmethyl phosphates, phosphonates and...

C - Chemistry, Metallurgy

07

F

C07F 9/547 (2006.01) A61K 31/675 (2006.01) C07F 9/6541 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2102592

NOVEL 2-SACCHARINYLMETHYL PHOSPHATES, PHOSPHONATES AND PHOSPHINATES USEFUL AS PROTEOLYTIC ENZYME: INHIBITORS AND COMPOSITIONS AND METHOD OF USE THEREOF ABSTRACT 4-R1-R2-R3-2-Saccharinylmethyl phosphates, phosphonates and phosphinates of formula I herein, useful in the treatment of degenerative diseases, and compositions containing them, methods for using them to treat degenerative diseases, and processes for their preparation by reaction of the corresponding 2-halomethylsaccharins with aphosphate, phosphonate or phosphinic acid of formula III herein in the presence of an acid- acceptor.

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