C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/234, 260/302
C07D 277/30 (2006.01) A61K 31/425 (2006.01) C07D 277/24 (2006.01) C07D 277/26 (2006.01) C07D 277/28 (2006.01) C07D 417/02 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2032282
- 1 - HOE 89/F 393 Abstract of the disclosure: Novel 2-substituted 4-(3-alky1-5-tert.-butyl-4-hydroxy- phenyl)thiazoles, processes for their preparation, pharmaceuticals containing them and their use Novel substituted thiazoles of the formula I Image (I) in which R1 is a saturated or unsaturated, straight-chain or branched Cl-C5-alkyl group, R2 is a hydrogen atom or an alkyl radical having 1 to 3 carbon atoms, A is an intermediate chain of the formula -(CH2)n-Y-CR3R4-;-CH=CR3-(CH2)m- or -CH=N-O-(CH2)n- where Y is a single bond, an oxygen or sulfur atom or a carbonyl group, R3 and R4 are identical or different and are a hydro- gen atom or an alkyl radical having up to two carbon atoms, m is a number from 0 to 3 and n is a number from 1 to 4, and Z is a tetrazole or CN group, or a radical of the formula Image X is a hydroxyl group or a radical of the formula R5O- or R6R7N-, where R5 is a straight-chain or branched Cl- C4-alkyl radical which is optionally substituted by hydroxyl, C1-C3-alkoxy or Cl-C3-alkylamino, R6 and R7 are identical or different and are a hydrogen atom, a straiqht-chain or branched - 2 - Cl-C6-alkyl radical or, for the case in which R6 is a hydrogen atom or a Cl-C4-alkyl radical, R7 is a hydroxyl, a Cl-C3-alkoxy or a tetrazol-5-yl group or X, together with the structural element -A-(C=O)-, is a radical of the formula II Image (II) where R8 is a hydrogen atom, a Cl-C3-alkyl radical or a C1-C3-alkoxy radical, and physiologically tolerable salts of such compounds of the formula I in which X is a hydroxyl or hydroxyamino group, are prepared by various processes. They are preferably suitable for the treatment and prophylaxis of inflammatory diseases - in particular inflammatory rheumatic diseases.
Bartlett Robert
Schleyerbach Rudolf
Thorwart Werner
Weithmann Klaus U.
Bartlett Robert
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
Schleyerbach Rudolf
Thorwart Werner
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