2'-substituted 1,1'-biphenyl-2-carboxamides, processes for...

Details 2'-substituted 1,1'-biphenyl-2-carboxamides, processes for... 2'-substituted 1,1'-biphenyl-2-carboxamides, processes for...

C - Chemistry, Metallurgy

07

C

C07C 271/22 (2006.01) A61K 31/165 (2006.01) A61K 31/27 (2006.01) A61K 31/4406 (2006.01) A61P 9/06 (2006.01) C07C 233/11 (2006.01) C07C 233/87 (2006.01) C07C 235/38 (2006.01) C07C 237/42 (2006.01) C07C 271/54 (2006.01) C07C 275/24 (2006.01) C07C 275/28 (2006.01) C07C 275/42 (2006.01) C07C 311/06 (2006.01) C07C 311/13 (2006.01) C07C 311/15 (2006.01) C07C 311/19 (2006.01) C07C 311/29 (2006.01) C07C 311/46 (2006.01) C07C 311/47 (2006.01) C07C 317/18 (2006.01) C07C 335/12 (2006.01) C07C 335/16 (2006.01) C07D 213

Patent

CA 2385859

2'-substituted 1,1'-biphenyl-2-carboxamides, processes for their preparation, their use as medicament, and pharmaceutical preparations comprising them Compounds of the formula I, (see formula I) in which R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel and antiarrythmic active compounds, in particular for the treatment and prophylaxis of atrial arrythmias, e.g. atrial fibrillation (AF), or atrial flutter.

Selon l'invention, les composés de la formule (I), dans laquelle R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) et R(31) ont les significations indiquées dans les revendications, sont particulièrement adaptés en tant qu'agents antiarrhythmiques, en particulier pour le traitement et la prévention des arrhytmies auriculaires, par exemple des fibrillations auriculaires ou des flutters auriculaires.

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