2-substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-...

Details 2-substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-... 2-substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-...

C - Chemistry, Metallurgy

07

D

260/276, 260/246

C07D 471/04 (2006.01)

Patent

CA 1215367

ABSTRACT OF THE DISCLOSURE: This invention relates to novel 2 - Substitued 1- (3'-amino-alkyl)-1,2,3,4-tetrahydro-.beta.-carbolines of the formula Image where n is an integer from 2 to 5, R is hydrogen, halogen, trifluoromethyl, C1-C4-alkyl or C1-C4-alkoxy, R2 is hydrogen or C1-C3-alkyl, R3 is C1-C3-acyl, R4 is hydrogen or an alkyl or cycloalkyl radical of not more than 4 carbon atoms ans R5 is hydrogen or an alkyl or cycloalkyl radical of not more than 4 carbon atoms and, where R is hydrogen, R5 may further- more be C1-C4-hydroxyalkyl or C2-C4- aminoalkyl in which the amine nitrogen atom can be substituted by C1-C3-alkyl or can form part of a 5-membered, 6-membered or 7-membered saturated ring, or R4 and R5, together with the nitrogen atom, form a 5-membered, 6-membered or 7-membered saturated ring which can be substituted by one or more C1-C3-alkyl groups, a hydroxyl group and/or a phenyl group, and to their preparation. These novel substances have powerful antiarrhythmic action that make them particularly useful for the pharmac therapy of cardiac arrhythmias.

433894

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