2-substituted-3,4-diarylthiophene derivatives as inhibitors...

C - Chemistry – Metallurgy – 07 – D

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C07D 333/04 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) C07D 333/18 (2006.01) C07D 333/28 (2006.01) C07D 333/44 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2161789

Disclosed are compounds of formula (I) use- ful in the treatment of cyclooxygenase mediated dis- eases such as pain, fever and inflammation of a va- riety of conditions including rheumatic fever, symp- toms associated with influenza or other viral infec- tions, common cold, low back and neck pnin, dys- menorrhea, headache, toothache, sprains and strains, myositis, neuralgia, synovitis, arthritis, including rheumatoid arthritis degenerative joint diseases (osteoarthritis), gout and ankylosing spondylitis, bursitis, burns, injuries and Alzheimer's disease. R3 is selected from the group consisting of (1) -S(O)2CH3,(2)-S(O)(NH)CH3,(3) -S(O)NH2, and (4) -S(O)2NH2.

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