C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/251, 260/300
C07D 209/12 (2006.01) C07D 213/55 (2006.01) C07D 403/04 (2006.01)
Patent
CA 1128944
ABSTRACT 2-Substituted-3-heterocyclyl-indoles of the formula Image I wherein X is a hydrogen or halogen atom, n is 1, 2 or 3 (when X is halogen atom), Q is an oxygen atom or the group (H,OH), Z is a hydrogen atom or, provided that Q is an oxygen atom, Z can also be the group OR, wherein R is a hydro- gen atom or a lower alkyl or loweralkoxy-loweralkyl group, m is 1 or 2 when Z is a hydrogen atom and m is O when Z is the group OR, and Het is a heterocyclic radical selected from pyridyl, lower-alkyl-substituted pyridyl, pyrimidinyl, pyrida- zinyl, pyrazinyl, pyrazolyl, imidazolyl, thiazolyl, iso- thiazolyl, thienyl, furanyl, pyrrolyl, oxazolyl and iso- xazolyl, have immuno-suppressant activity and can be used for example in the treatment of rheumatoid arthritis. Their preparation and pharmaceutical compositions contai- ning them are also described.
336840
Steinman Martin
Tahbaz Pirouz
Schering Corporation
Swabey Ogilvy Renault
LandOfFree
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