2-substituted-3-hydroxythiazolo 2,3-b benzo-(and...

Details 2-substituted-3-hydroxythiazolo 2,3-b benzo-(and... 2-substituted-3-hydroxythiazolo 2,3-b benzo-(and...

C - Chemistry, Metallurgy

07

D

260/273, 260/309

C07D 277/74 (2006.01) C07D 513/04 (2006.01) C07D 513/14 (2006.01)

Patent

CA 1151171

ABSTRACT OF THE DISCLOSURE The present invention provides compounds Image wherein R1 is hydrogen, halo, amino, lower alkyl, lower al- koxy, trifluoromethyl or hydroxy; R2 is lower alkyl, acetyl, trifluoroacetyl, phenyl or phenyl substituted with fluorine, chlorine, bromine, lower alkyl, lower alkoxy, amino, nitro or trifluoromethyl; X is CH or N and the dotted lines repre- sent optional double bonds in the 5,6 and 7,8 positions, which are intermediates in the preparation of novel 2-substi- tuted-3-hydroxythiazole[2,3-b]benzo-(and azabenzo)thiazolium salts, the mesoionic didehydro derivatives thereof and rela- ted compounds which intermediates are also useful as modula- tors of the immune response.

394992

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