2-substituted 4,5-diphenyl-imidazoles

Details 2-substituted 4,5-diphenyl-imidazoles 2-substituted 4,5-diphenyl-imidazoles

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07D 233/84 (2006.01) C07D 233/94 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2073443

2073443 9110662 PCTABS00006 Imidazole derivatives of formula: [DPIM]-S(O)p-W-Y, wherein [DPIM] is of formula (I), wherein R and R1 each represents hydrogen, halogen, alkyl or alkoxy, p is 0, 1 or 2, W represents alkylene, Y represents an optionally substituted 5- or 6-membered unsaturated ring containing 1 to 4 nitrogen atoms, and pharmaceutically acceptable acid addition salts thereof, are inhibitors of acyl coenzyme-A:cholesterol-O-acyle transferase and of the binding of thromboxane TxA2 to its receptors and are useful in therapy.

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