2-substituted 4,5-diphenylthiazoles and synthesis thereof

Details 2-substituted 4,5-diphenylthiazoles and synthesis thereof 2-substituted 4,5-diphenylthiazoles and synthesis thereof

C - Chemistry, Metallurgy

07

D

260/302, 260/278

C07D 417/02 (2006.01) C07D 277/22 (2006.01) C07D 277/28 (2006.01) C07D 277/42 (2006.01) C07D 295/00 (2006.01) C07D 295/15 (2006.01)

Patent

CA 1036600

Abstract of the Disclosure A new class of substituted thiazole compounds is described of the formula; Image wherein R1 and R2 when considered separately are each hydrogen, C1-C4 alkyl, C1-C4 hydroxyalkyl C1-C4 acyl or acyloxyalkyl having 1 to 4 carbon atoms is the alkyl chain, and R1 and R2 when taken together with the nitrogen atom to which they are attached form a heterocyclic amino radical selected from the group consisting of morpholino, piperidino, and pyrrolidino; and A' represents an alkylene group having 1 to 4 carbon atoms or a single bond. The compounds show string inhibitory action of platelet aggregation, often associated with a significant hypocholesterolemic activity.

218709

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