2-substituted-6-trifluoromethyl purine derivatives with...

Details 2-substituted-6-trifluoromethyl purine derivatives with... 2-substituted-6-trifluoromethyl purine derivatives with...

C - Chemistry, Metallurgy

07

D

C07D 473/00 (2006.01) A61K 31/52 (2006.01) A61P 29/00 (2006.01) A61P 35/02 (2006.01) C07D 473/40 (2006.01)

Patent

CA 2579302

The present invention relates to 2-substituted-6-trifluoromethyl purine derivatives as selective adenosine antagonists, in particular adenosine -A3 receptor antagonists, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said purine derivatives. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

L'invention concerne des dérivés de 6-trifluorométhyl purine de substitution en 2 comme antagonistes sélectifs de l'adénosine, plus précisément des antagonistes du récepteur de l'adénosine A3; elle concerne également des procédés permettant de préparer ces composés ainsi que de nouveaux intermédiaires utilisés pour la synthèse desdits dérivés de la purine. Lesdits composés présentent la formule générale (1), dans laquelle les symboles ont la signification donnée dans le descriptif.

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