2-substituted alkyl-3-carboxy carbapenems as antibiotics and...

C - Chemistry – Metallurgy – 07 – D

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C07D 205/00 (2006.01) A61K 31/395 (2006.01) C07D 205/08 (2006.01) C07D 477/00 (2006.01) C07D 477/14 (2006.01)

Patent

CA 2039968

31,291 NOVEL 2-SUBSTITUTED ALKYL-3-CARBOXY CARBAPENEMS AS ANTIBIOTICS AND A METHOD OF PRODUCING THEM ABSTRACT The invention relates to new 2-substituted alkyl-3-carboxy carbapenems having the formula: Image with R1, R2, R3, X and Y defined in the specification as antibiotics and beta lactamase inhibitors produced by a novel Michael addition-elimination reaction of a substituted allyl azetidinone in the reaction shown: Image with Q defined in the specification.

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