2-substituted-amino-pyrimidin-4-one compounds

Details 2-substituted-amino-pyrimidin-4-one compounds 2-substituted-amino-pyrimidin-4-one compounds

C - Chemistry, Metallurgy

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C07D 417/00 (2006.01) A61K 31/425 (2006.01) A61K 31/505 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 213/58 (2006.01) C07D 239/47 (2006.01) C07D 253/06 (2006.01) C07D 277/48 (2006.01)

Patent

CA 1218066

ABSTRACT OF THE DISCLOSURE The invention relates to a heterocyclic derivative of the formula: Image where D is O, S or NH; E is CH or when D is O or S, E is N; Y is S, O, CH2, SO or a direct bond; m is 0 to 4 and n is 1 to 4, provided that when Y is S, O or SO m is 1 to 4, and when Y is O or SO, n is 2 to 4; A is C(3-4) chain comprising at least one C and also optionally S, N, 2N or N and S, and also comprising C=O or C=S or where possible SO2 and chain optionally sub- stituted by 1 or 2 C(1-6)alkyl, benzyl, naphthylmethyl, 2-phenethyl, 4-phenylbutyl, pyridylmethyl, thiazolyl- methyl, thienylmethyl, benzyloxy, pyridylmethoxy or phenoxymethyl radicals each optionally substituted on the aromatic ring system by 1 to 3 halogen atoms or methyl, methoxy, trifluromethyl, dimethylamino, phenyl or phenoxy radicals; and the salts thereof. The compounds of the invention are histamine H-1-antagonists and inhibit secretion of gastric acids.

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