C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01)
Patent
CA 2228136
The present invention addresses 2-substituted aryl pyrroles, as well as compositions containing such compounds and methods of treatment. Cytokine mediated diseases refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved.
L'invention se rapporte à des pyrroles d'aryle substitués en position 2, ainsi qu'à des compositions contenant de tels composés et à leurs modes d'utilisation. Les maladies induites par les cytokines sont des maladies ou des pathologies dans lesquelles intervient la production ou l'activité excessive ou non contrôlée d'une ou de plusieurs cytokines. L'interleukine-1 (IL-1), l'interleukine-6 (IL-6), l'interleukine-8 (IL-8) et le facteur de nécrose tumorale (TNF) figurent parmi les cytokines impliquées.
de Laszlo Stephen E.
Liverton Nigel J.
Mantlo Nathan B.
Ponticello Gerald S.
Selnick Harold G. .
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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