2-substituted benzimidazole derivatives

Details 2-substituted benzimidazole derivatives 2-substituted benzimidazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 235/08 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07D 235/10 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2223962

Disclosed herein are compounds of formula (I) where R1 is alkyl, trifluoromethyl or pyridinyl; R2 is H, alkyl or substituted arylalkyl, in which the substituents are independently one or two halogens, carboxyl or alkoxycarbonyl groups; R3 and R4 are H, alkyl, halogen or nitro; or a pharmaceutically acceptable salt thereof, which are useful as inhibitors of smooth muscle cell proliferation.

L'invention porte sur des composés de la formule (I) dans laquelle R¿1? représente alkyle, trifluorométhyle ou pyridinyle; R¿2? représente H, alkyle ou arylalkyle substitué où les substituants valent indépendamment un ou deux halogènes, des groupes carboxyles ou alcoxycarbonyles; R¿3? et R¿4? représentent H, alkyle, halogène ou nitro. L'invention porte également sur un sel de ladite formule acceptable sur le plan pharmaceutique. Ces dérivés s'avèrent bénéfiques comme inhibiteurs de la prolifération de cellules des muscles lisses.

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