2-substituted benzofuran derivatives and methods of preparation

Details 2-substituted benzofuran derivatives and methods of preparation 2-substituted benzofuran derivatives and methods of preparation

C - Chemistry, Metallurgy

07

D

260/361, 260/266

C07D 307/78 (2006.01) C07D 307/80 (2006.01) C07D 307/81 (2006.01) C07D 307/86 (2006.01) C07D 307/92 (2006.01) C07D 405/02 (2006.01) C07D 413/02 (2006.01)

Patent

CA 1182454

ABSTRACT a 2-substituted benzofuran derivative of general formula or II Image (I) Image (II) in which R1 and R2, can be the same or different, and are a hydrogen atom, a halogen atom, an alkyl group containing 1 to 4 carbon atoms, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH2, NH-alkyl, N(alkyl)2, NH(CO-alkyl), NH(CO-aryl) or NO2 group, or R1 and R2 can together form a ring of 5-8 carbon atoms; R3 is a hydrogen atom, an alkyl group containing 1 to 4 carbon atoms or an aryl group; R4 is a hydrogen atom, an alkyl group, an aryl or an arylalkyl group, R5 is a hydroxyl group, an alkoxy group, an OCO-aryl, OCOHN-alkyl or OCONH-aryl group, an Image group, an Image group or an Image group, where n ls a number between 1 and 4, R7 is a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, and R8 and R9, which can be the same or different, represent a hydrogen atom, an alkyl group, an aryl group, an alkoyl group, arylalkoyl group or an aroyl group, or can together form a heterocyclic ring which can contain supplementary heteroatoms, and R6 is a hydrogen or halogen atom, an alkyl group, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH2, NH-alkyl, N(alkyl)2, NHCO-alkyl, NHCO-aryl or NO2 group. These compounds exhibit useful antihistamine, local anaesthetic, anti-arrhythmic, muscle relaxant and antiepileptic activity.

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