2-substituted benzothiazole derivatives and prophylactic and...

Details 2-substituted benzothiazole derivatives and prophylactic and... 2-substituted benzothiazole derivatives and prophylactic and...

C - Chemistry, Metallurgy

07

D

C07D 277/62 (2006.01) A61K 31/425 (2006.01) C07D 277/64 (2006.01) C07D 277/74 (2006.01)

Patent

CA 2163950

Unique benzothiazole derivatives which exert superior aldose redactase inhibiting actions are unexpectedly and advantageously useful in the prophylactic and therapeutic treatment of diabetic complications. A benzothiazole derivative compound of the formula (1): Image (1) wherein X is halogen, R1 and R2, which are the same or different, are each independently hydrogen or halogen, A is a methylene group or a sulfur atom, and -B-COOR3 is a group selected from the group consisting of (2) to (5): Image Image (2) (3) Image --(CH2)m--COOR3 (4) (5) wherein R3 is hydrogen or C1 to C3 lower alkyl, Y is hydrogen, halogen, C1 to C3 lower alkyl, carboxyl or dilower alkylamino and n is an integer of 1 to 3; Z is oxygen or sulfur, R4 is C1 to C3 lower alkyl, optionally substituted phenyl, optionally substituted benzyl or optionally substituted phenethyl and m is an integer of 2 to 5; or a pharmaceutically acceptable salt and a pharmaceutical composition comprising the same which is a useful prophylactic or therapeutic agent for the treatment of diabetic complications.

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