2-substituted-e-fused-¬1,2,4|triazolo¬1,5- c|pyrimidines,...

Details 2-substituted-e-fused-¬1,2,4|triazolo¬1,5- c|pyrimidines,... 2-substituted-e-fused-¬1,2,4|triazolo¬1,5- c|pyrimidines,...

C - Chemistry, Metallurgy

07

D

167/218, 260/228

C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 487/14 (2006.01) C07D 495/14 (2006.01) C07H 17/02 (2006.01)

Patent

CA 1317590

4-16385/15519/=/CGC 1151 2-SUBSTITUTED-E-FUSED-[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Abstract of the Disclosure Compounds of the formula Image (I) wherein R1 is optionally substituted phenyl, pyridyl, thienyl, furyl, pyrrolyl, thiazolyl, or ribofuranosyl; X is oxygen, NR, or sulfur; R is hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; and ring A is a) an optionally substituted 5-8 membered monocycloalken-1,2-diyl; b) an optionally substituted carbobicyclic ring of the formula Image (II) wherein n and m are each independently one or two; or c) an optionally substituted 5-6 membered heterocycle having one or two heteroatoms, the atoms of which are selected from carbon, oxygen, nitrogen, and sulfur. Also disclosed are tautomers of the above and pharmaceutically acceptable salts; compositions thereof; and methods of using the compounds, tautomer, or salts.

547940

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