2-substituted ergoline derivatives, processes for their...

Details 2-substituted ergoline derivatives, processes for their... 2-substituted ergoline derivatives, processes for their...

C - Chemistry, Metallurgy

07

D

260/206

C07D 457/00 (2006.01) C07D 457/02 (2006.01) C07D 457/12 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1291119

Abstract Novel ergoline derivatives, substituted in the 2-position, of the formula Image (I), wherein C8?C9 and C9?C10 each independently is a CC-single or a C=C-double bond, but not together a cumulated double bond, and the substi- tuent in the 8-position is in the .alpha.- or .beta.-configuration where C8?C9 is a CC-single bond, R2 is CN, SR, SOR, Image wherein n is 2 or 3, -?R and -CH(OH)R wherein R has the meaning of H or C1-4-alkyl, the grouping COR' and CSR' wherein R' = OH, OC1-4-alkyl, benzyl, NH2 or NHR", the grouping CH=CH-CO2R" and CH2-CH2-CO2R" wherein R" = C1-4-alkyl, the grouping C?C-R''' and HC=CH-R''' wherein R''' a hydrogen, C1-4-alkyl, phenyl, CH2OH, CR"2OH, Image CO2R", CH2NR"2 or SiMe2R"; C1-3-alkyl, or C1-3-alkyl sub- stituted by OH or phenyl; or Image wherein R" is C1-4 alkyl, R6 is C1-4-alkyl and R8 is methyl, NH-CO-NEt2 or NH-CS-NEt2, and the physiologically acceptable acid addition salt thereof, possess biological efficacy in the region of the central nervous system, e.g., as neuroleptics and anti- depressants.

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