2-(substituted imino)-6-aryl-3,6-dihydro-4-...

Details 2-(substituted imino)-6-aryl-3,6-dihydro-4-... 2-(substituted imino)-6-aryl-3,6-dihydro-4-...

C - Chemistry, Metallurgy

07

D

167/208, 260/255

C07D 239/22 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01)

Patent

CA 1275409

Abstract 2-(SUBSTITUTED IMINO)-6-ARYL-3,DIHYDRO-4- SUBSTRITUTED-1,5(2H)-PYRIMIDINECARBOXYLIC ACIDS AND ANALOGS Cardiovascular activity is exhibited by compounds having the formula Image and pharmaceutically acceptable salts thereof, wherein R1 is alkyl, cycloalkyl, aryl, heterocyclo, -(CH2)n-Y2, -(CH2)p-Y3 or halo substituted alkyl; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, -(CH2)n-Y1, or halo substituted alkyl; R3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, -(CH2)n-Y2, -(CH2)p-Y3, or substituted alkyl; R4 is aryl or heterocyclo; R5 is hydrogen, alkyl, aryl, arylalkyl, cyano, nitro, alkyl-?-, aryl-?-, arylalkyl-?-, alkyl-?-, aryl-?-, arylalkyl-?-, -(CH2)n-Y2, or (CH2)p-Y3; Y1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, amino, substituted amino, carbamoyl, (substituted amino)-?-, heterocyclo-(CH2)m-?-, carboxyl, alkoxycarbonyl, alkyl-?-, aryl-(CH2)m-?-, alkyl-?- or aryl-(CH2)m-?-O-; Y2 is cycloalkyl, aryl, heterocyclo, carbamoyl, (substituted amino)-?-, carboxyl, alkoxycarbonyl, alkyl-?-, aryl-(CH2)m-?-, or heterocyclo-(CH2)m-?-; Y3 is hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, alkyl-?-O-, aryl-(CH2)m-?-O-, amino, or substituted amino; m is 0 or an integer of 1 to 6; n is an integer of 1 to 6; and p is an integer of 2 to 6.

528079

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