C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/18 (2006.01) A61K 31/425 (2006.01)
Patent
CA 2063865
2-(Substituted imino)-thiazolidines and process for the preparation thereof A B S T R A C T The invention relates to new 2-(substituted imino)-thiazolidines, a process for the preparation thereof, pharmaceutical compositions comprising the same, the use of the said 2-(substituted imino)- -thiazolidines for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new 2-(substituted imino)-thiazolidine derivatives provided by the present invention corre- spond to the general formula (I), Image (I) wherein R1 and R2 each represent halogen, nitro, C1-4 alkoxy or C1-4 alkyl, which latter may optionally carry one or more halogen substituent(s), R3 and R4 each represent hydrogen or C1-4 alkyl, Z denotes oxygen, sulfur or imino, which latter is substituted by a C1-6 alkyl or a C1-6 alkenyl group, R5 stands for hydrogen, C1-4 alkyl, C1-4 aikylthio or a group or the formula -NH-R, wherein R repre- sents C1-6 alkyl, aryl, aralkyl or C1-6 alkenyl optionally carrying a halogen or a di-(C1-4 al- kyl)-amino substituent; or Z and R5 together stand for a trivalent nitrogen atom, with the proviso that if Z denotes a substi- tuted imino group, R5 stands for C1-4 alkylthio, and if R5 is C1-4 alkylthio, Z represents a substituted imino, and with the further proviso that if Z de- notes sulfur, R5 is other than hydrogen or C1-4 al- kyl, and possess valuable antianginal and analgesic properties.
Fekete Marton
Feller Antal
Fetter Jozsef
Gado Klara
Gigler Gabor
Egis Gyogyszergyar Rt.
Fetherstonhaugh & Co.
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