C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/55 (2006.01) C07D 487/04 (2006.01) C07D 491/147 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2078758
The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide derivatives of the formula (See formula I) wherein B1 and B2 are each independently hydrogen, hydroxy, -OR2 wherein R2 is a C1-C4 alkyl or an Ar-Y group wherein Ar is aryl and Y is a hydrogen or C1-C4 alkyl, or, where B1 and B2 are attached to adjacent carbon atoms, B1 and B2 can be taken together with said adjacent carbons to form a benzene ring or methyl- enedioxy; A is a bond, methylene, oxygen, sulfur, NR4 or NCOR5 wherein R4 is hydrogen, a C1-C4 alkyl or an Ar-Y- group and R5 is -CF3, a C1-C10 alkyl or an Ar-Y- group; R1 is hydrogen, acetyl, -CH2OC(O)C(CH3)3 or benzoyl; R3 is hydrogen or -CH2OC(O)C(CH3)3; n is an integer 0 to 3; and Q is a group of the formula (See formulas I,II,III,IV, and V) wherein Z is O, NH or S; and m is an integer 1 to 5; which are useful as inhibitors of enkephalinase and ACE.
Flynn Gary Alan
Warshawsky Alan M.
Merrell Dow Pharmaceuticals Inc.
Merrell Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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