C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 265/28 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/675 (2006.01) C07D 265/30 (2006.01) C07D 265/34 (2006.01) C07D 279/12 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07F 9/6533 (2006.01)
Patent
CA 2158952
Disclosed are compounds of Formula (I) wherein: Y represents -CO2H, -CO2R6, -C(O)NHR7, -SO2H, -SO3H, -SO3R6, -SO2NHR7, -C(O)-N(OH)-R8, or a group of formula (a), (b), (c), (d) or (e); or a pharmaceutically acceptable addition salt or solvate thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula (I). Further disclosed is a method for treating or preventing respiratory depression, epileptic seizures or other central nervous system disorders, and for enhancing cognitive performance, by administering an effective amount of a compound of Formula (I).
L'invention concerne des composés de la formule (I). Dans cette formule, Y représente -CO2H, -CO2R6, -C(O)NHR7. -SO2H, -SO3H. -SO3R6, -SO2NHR7, -C(O)-N(OH)-R8 ou un groupe de la formule (a), (b), (c), (d) ou (e) ainsi que leur sel d'addition ou solvate acceptables sur le plan pharmaceutique. L'invention concerne également des compositions pharmaceutiques contenant des composés de la formule (I). L'invention concerne en outre un procédé pour traiter ou prévenir des insuffisances respiratoires, des crises d'épilepsie ou d'autres troubles du système nerveux central et pour augmenter les capacités cognitives, par administration d'une dose efficace d'un composé de la formule (I).
Blythin David J.
Kreutner William
Kuo Shen-Chun
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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