2-substituted n,n'-ditrimethoxybenzoyl piperazines, a...

Details 2-substituted n,n'-ditrimethoxybenzoyl piperazines, a... 2-substituted n,n'-ditrimethoxybenzoyl piperazines, a...

C - Chemistry, Metallurgy

07

D

167/223, 260/267

C07D 241/04 (2006.01) A61K 31/495 (2006.01) C07D 295/192 (2006.01)

Patent

CA 2014521

This invention relates to piperazine derivatives of the general formula I (see fig.I) wherein -(CH2)n- represents a straight or branched chain alkyl group having from n = 1 to n = 20 carbon atoms, and R represents a hydrogen atom, a branched alkyl rest, a cycloalkyl group having from 5 to 10 carbon atoms, a phenyl group, optionally substituted by one or several chlorine atoms, methyl or methoxy groups, or straight or branched chain alkenyl groups having from 3 to 11 carbon atoms, to a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.

'invention concerne des dérivés de la pipérazine de formule générale I (voir fig.I) où -(CH2)n- représente un groupe alkyle à chaîne linéaire ou branchée de n = 1 à n = 20 atomes de carbone, et R est un atome d'hydrogène, un résidu alkyle branché, un groupe cycloalkyle possédant entre 5 et 10 atomes de carbone, un groupe phényle, facultativement substitué par un ou plusieurs atomes de chlore, des groups méthyle ou méthoxy, ou des groups alkényle à chaîne linéaire ou branchée ayant de 3 à 11 atomes de carbone; l'invention concerne également un procédé de préparation desdits composés et des compositions thérapeutiques contenant ces composés comme ingrédients actifs.

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