2'-substituted nucleosides and oligonucleotide derivatives

Details 2'-substituted nucleosides and oligonucleotide derivatives 2'-substituted nucleosides and oligonucleotide derivatives

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2256765

The invention relates to an oligonucleotide derivative which comprises at least one nucleoside building block of the formula (I). The invention furthermore relates to nucleoside building blocks, intermediates and processes for preparing the oligonucleotide derivatives and the nucleoside building blocks. The invention also relates to pharmaceutical compositions and to uses of the oligonucleotide derivatives and the nucleoside building blocks.

L'invention concerne un dérivé oligonucléotidique comprenant au moins un élément constitutif nucléoside de la formule (I); elle concerne en outre des éléments constitutifs nucléoside, des intermédiaires ainsi que des procédés de préparation de dérivés oligonucléotidique et d'éléments constitutifs nucléoside. L'invention concerne encore des compositions pharmaceutiques ainsi que l'utilisation de dérivés oligonucléotidiques et d'éléments constitutifs nucléoside.

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