2-substituted proline bis-amide orexin receptor antagonists

Details 2-substituted proline bis-amide orexin receptor antagonists 2-substituted proline bis-amide orexin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4184 (2006.01) A61P 25/20 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2657787

The present invention is directed to 2-substituted proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

La présente invention concerne des composés de proline bis-amide substitués en position 2 qui sont des antagonistes des récepteurs de l'oréxine et qui sont utilisables pour le traitement ou la prévention de troubles ou de maladies neurologiques ou psychiatriques dans lesquels les récepteurs de l'oréxine sont impliqués. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions pour la prévention ou le traitement des maladies dans lesquelles les récepteurs de l'oréxine sont impliqués.

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