C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) C07D 239/94 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 491/10 (2006.01) C07D 519/00 (2006.01) C07F 9/6512 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2509233
Certain 2-substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
L'invention concerne certains analogues de quinazolin-4-ylamine 2-substituée. Ces composés constituent des ligands pouvant servir à moduler l'activité de récepteurs spécifiques <i>in vivo</i> ou <i>in vitro</i>, et sont particulièrement utiles dans le traitement de troubles associés à l'activation pathologique de récepteurs chez l'être humain, les animaux domestiques et le bétail. L'invention concerne des compositions pharmaceutiques et des procédés d'utilisation de celles-ci pour traiter de tels troubles, et des procédés d'utilisation de ces ligands pour étudier la localisation de récepteurs.
Bakthavatchalam Rajagopal
Blum Charles A.
Brielmann Harry
Caldwell Timothy M.
de Lombaert Stephane
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Neurogen Corporation
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