2-(substituted sulfamyl)-6-nitrobenzoic acids, useful as...

Details 2-(substituted sulfamyl)-6-nitrobenzoic acids, useful as... 2-(substituted sulfamyl)-6-nitrobenzoic acids, useful as...

C - Chemistry, Metallurgy

07

C

260/336, 260/247

C07C 311/24 (2006.01) C07D 241/08 (2006.01) C07D 295/26 (2006.01)

Patent

CA 1274518

ABSTRACT OF THE DISCLOSURE Derivatives of 2-(substituted sulfamyl)- 6-nitrobenzoic acids are disclosed, wherein at least one of the sulfamyl substituents is selected from amino-(lower alkyl), (lower alkyl)-amino-(lower alkyl), or di(lower alkyl)-amino-(lower alkyl), hydrogen, lower alkyl, hydroxy-(lower alkyl), allyl, or when taken together with the nitrogen of the sulfamyl moiety, form a heterocyclic ring. These compounds have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds ana pharmaceutical compositions including such compounds.

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