2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives

Details 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 233/86 (2006.01) A61K 31/415 (2006.01) A61K 31/4166 (2006.01)

Patent

CA 2238812

The compounds of formula (I): wherein R is phenyl or phenyl optionally substituted with one or more groups selected from halogen, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, hydroxy, alkanoyloxy, aroyloxy or arylalkanoyloxy; R3 is alkyl, aryl or arylalkyl; or a pharmaceutically acceptable salt thereof, are use for increasing HDL blood levels.

L'invention concerne un composé de la formule (I). Dans cette formule, R est un phényle éventuellement substitué avec un ou plusieurs groupes choisis parmi: halogène, alkyle, perfluoroalkyle, alcoxy, perfluoroalcoxy, hydroxy, alcanoyloxy, aroyloxy ou arylalcanoyloxy; R?3¿ est un alkyle, aryle ou aralkyle. L'invention concerne également les sels de ces composés acceptables sur le plan pharmaceutique. Ces dérivés et leurs sels sont utiles pour augmenter les niveaux de HDL dans le sang.

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