2-substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-...

Details 2-substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-... 2-substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-...

C - Chemistry, Metallurgy

07

D

260/276

C07D 471/04 (2006.01)

Patent

CA 1163996

ABSTRACT A 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-lH-pyrido [4,3-b] indole derivative of the formula Image wherein Xl and Yl are the same or different and are each hydrogen or fluoro is prepared by reacting a compound of the formula Image wherein R2 is benzyl, benzhydryl, ZlC6H4 IH(CH2)n - or substituted OH benzyl; Zl is H, F or -OCH3; and n is 3 or 4, with a lower alkyl chloroformate, followed by alkaline hydrolysis. The prepared compound is useful as an intermediate for the production of a tranquilizing agent.

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