2-substituted vitamin d analogues and their therapeutic uses

Details 2-substituted vitamin d analogues and their therapeutic uses 2-substituted vitamin d analogues and their therapeutic uses

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2518531

The present invention relates to analogues of vitamin D namely 14-epi-2-alkyl- 19-nor vitamin D derivatives. Also a general method for the synthesis and the biological activities are described. The general formula is: (I) where R (.alpha. or .beta. oriented) represents an alkyl substituent and X part of a typical side chain of vitamin D or of one of its established analogues.

La présente invention a trait à des analogues de la vitamine D notamment des dérivés de la vitamine D 14-épi-2-alkyl-19-nor. L'invention a également trait à un procédé général pour la synthèse et les activités biologiques. La formule générale est (I), dans laquelle : R ( à orientation .alpha. ou .beta.) représente un substituant alkyle et X représente une partie de la chaîne latérale typique de la vitamine D ou d'un de ses analogues connus.

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