2-sulfinyl- and 2-sulfonyl-substituted imidazole derivatives...

Details 2-sulfinyl- and 2-sulfonyl-substituted imidazole derivatives... 2-sulfinyl- and 2-sulfonyl-substituted imidazole derivatives...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/435 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2599449

The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula (I) in which the radicals R1, R2, R3 and R4 have the meaning indicated in the description. The compounds of the invention have an immunomodulating and/or cytokine release-inhibiting effect and are therefore suitable for the treatment of disorders associated with an impairment of the immune system.

La présente invention concerne des dérivés d~imidazole de 2-sulfinyle et de 2-sulfonyle de la formule (I) dans laquelle les radicaux R1, R2, R3 et R4 possèdent la signification indiquée dans la description. Les composés de l~invention présentent un effet immunomodulateur et/ou d~inhibition de libération des cytokines et, par conséquent, sont appropriés pour le traitement de désordres associés aux troubles du système immunitaire.

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