2-sulfonylamino-4-heteroaryl butyramide antagonists of ccr10

Details 2-sulfonylamino-4-heteroaryl butyramide antagonists of ccr10 2-sulfonylamino-4-heteroaryl butyramide antagonists of ccr10

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61P 11/00 (2006.01) A61P 17/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2720613

This invention relates to a com-pound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activ-ity of CCR10.

Cette invention porte sur un composé de formule (I) et sur les sels pharmaceutiquement acceptables de celui-ci, formule dans laquelle R1, R2, R4, Ar et Het sont tels que définis présentement. L'invention porte également sur des procédés d'utilisation du composé de formule (I) pour traiter des maladies et des troubles qui sont à médiation ou entretenus par l'activité de CCR10.

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