2-thia-dibenzoazulenes as inhibitors of tumour necrosis...

C - Chemistry – Metallurgy – 07 – D

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C07D 495/04 (2006.01) A61K 31/38 (2006.01) C07D 333/80 (2006.01)

Patent

CA 2481514

The present invention relates to compounds of 2-thia-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-.alpha. (TNF- .alpha.) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

L'invention concerne des composés de la classe de 2-thia-dibenzoazulène, les solvates et sels pharmacologiquement acceptables de ces composés, les procédés et les intermédiaires de préparation de ces composés ainsi que leurs effets anti-inflammatoires. L'invention concerne particulièrement l'inhibition de la production du facteur onconécrosant ? (TNF-?) et l'inhibition de la production de l'interleukine 1 (IL-1), ainsi que l'action analgésique des composés précités.

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