2-thio-substituted imidazole derivatives and their use in...

Details 2-thio-substituted imidazole derivatives and their use in... 2-thio-substituted imidazole derivatives and their use in...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4164 (2006.01) A61P 43/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2453078

The invention relates to 2-thio-substituted imidazole derivatives of formula I, wherein the groups R1, R2, R3 and R4 are defined as per the description. The inventive compounds have an immunomodulating action and/or an inhibitive action on the release of cytokine and are therefore suitable for treating diseases, which are related to the dysfunction of the immune system.

L'invention concerne des dérivés d'imidazole substitués par thio en position 2, de formule (I), dans laquelle les groupes R¿1?, R¿2?, R¿3? et R¿4? ont la signification indiquée dans la description. Ces composés présentent un effet immunomodulateur et/ou un effet inhibiteur sur la libération de cytokine et sont par conséquent appropriés pour traiter des maladies liées à un dysfonctionnement du système immunitaire.

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