C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/86 (2006.01) A61K 31/415 (2006.01) A61K 31/4166 (2006.01) A61K 31/4174 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) C07D 401/04 (2006.01)
Patent
CA 2238762
Compounds and a method for increasing the HDL cholesterol concentration in the blood of a mammal in need of increased HDL cholesterol blood concentration, which comprises administering to said mammal, orally or parenterally, a compound of formula (I) wherein R is alkyl; a substituted or unsubstituted aromatic N, O or S heterocycle; substituted or unsubstituted aryl, arylalkyl, benzhydryl or indanyl, in which the substituents are one to three members independently selected from the group consisting of alkyl, alkoxy, alkylthio, alkenyl, alkynyl, halo, perfluoroalkyl, perfluoroalkoxy or hydroxy; and R1 is aryl, alkyl, alkenyl, alkynyl or substituted aryl where the substituents are one to three members independently selected from the group consisting of alkyl, alkoxy, alkylthio, alkenyl, alkynyl, halo, perfluoroalkyl, perfluoroalkoxy or hydroxy.
Composés et procédé permettant d'augmenter la concentration en cholestérol à lipoprotéines de haute densité (HDL) dans le sang d'un mammifère nécessitant une concentration accrue de cholestérol HDL, ledit procédé consistant à administrer audit mammifère, par voie orale ou parentérale, un composé de formule (I). Dans la formule (I), R représente alkyle; un hétérocycle N, O, ou S aromatique substitué ou non; aryle, arylalkyle, benzhydryle ou indanyl substitué ou non dans lequel les substituants peuvent être un, deux ou trois éléments indépendamment sélectionnés dans le groupe formé par: alkyle, alcoxy, akylthio, alcényle, alcynyle, halo, perfluoroalkyle, perfluoroalcoxy ou hydroxy; et R?1¿ représente aryle, alkyle, alcényle, alcynyle ou aryle substitué dans lequel les substituants peuvent être un, deux ou trois éléments indépendamment sélectionnés dand le groupe formé par: alkyle, alcoxy, alkythio, alcényle, alcynyle, halo, perfluoroalkyle, perfluoroalcoxy ou hydroxy.
Chai Sie-Yearl
Elokdah Hassan Mahmoud
Strike Donald Peter
Sulkowski Theodore Sylvester
American Home Products Corporation
Ridout & Maybee Llp
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