2-thioxotetrahydropyrimidin-4-one derivatives

Details 2-thioxotetrahydropyrimidin-4-one derivatives 2-thioxotetrahydropyrimidin-4-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/22 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2247933

This invention relates to the use of 2-thioxotetrahydropyrimidin-4-one derivatives to increase HDL cholesterol concentration and as therapeutic compositions for treating atherosclerotic conditions such as dyslipoproteinemias and coronary heart disease. The compounds of this invention are represented by formula (a), wherein: R is C1-C6 alkyl or C2-C6 alkenyl; and R1, R2, and R3 are independently hydrogen, halogen or lower alkyl.

L'invention concerne l'utilisation de dérivés de la 2-thioxotétrahydropyrimidin-4-one pour augmenter la concentration en cholestérol des LPHD et des compositions thérapeutiques contenant de tels dérivés, pour traiter des états athéroscléreux tels que les dyslipoprotéinémies et les coronaropathies. Les composés de cette invention sont représentés par la formule (a). Dans cette formule, R est alkyle C¿1-6? ou alcényle C¿2-?C¿6? et R?1¿, R?2¿ et R?3¿ sont, d'une manière indépendante, hydrogène, halogène ou alkyle inférieur.

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