20-0-acylmaytansinoids

Details 20-0-acylmaytansinoids 20-0-acylmaytansinoids

C - Chemistry, Metallurgy

07

D

260/237.1, 260/2

C07D 498/18 (2006.01) C12P 17/18 (2006.01)

Patent

CA 1131629

20-O-ACYLMAYTANSINOIDS Abstract of the Disclosure Novel 20-demethoxy-20-acyloxymaytansinoids represent- able by the formula: Image (wherein X is chlorine or hydrogen; R1 is hydrogen or acyl group; R2 is acyl group) are produced from 20- demethoxy-20-hydroxymaytansinoids by means of acylation. The compounds are useful as antifungal, anti- protozoal or antitumor agent.

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