A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/351 (2006.01) C07D 309/04 (2006.01)
Patent
CA 2580962
The invention provides vitamin D3 analogs of cholecalciferol, substituted at carbon-20 with cycloalkyl, e.g., cyclopropyl, wherein carbon-16 is a double bond, and carbon-23 is a single, double, or triple bond. Various alkyl or haloalkyl substitutions are incorporated at carbon-25. The invention provides pharmaceutically acceptable esters, salts, and prodrugs thereof. Methods for using the compounds to treat vitamin D3 associated states, and pharmaceutical compositions containing the compounds are also disclosed.
L'invention concerne des analogues de vitamine D3 de cholécalciférol substitués en carbone 20 par cycloalkyle, tel que cyclopropyle, le carbone 16 étant une double liaison et le carbone 23 étant une liaison simple, double ou triple. Diverses substitutions alkyle ou haloalkyle sont introduites en carbone 25. L'invention concerne des esters, des sels et des promédicaments de ceux-ci pharmaceutiquement acceptables. L'invention se rapporte en outre à des procédés destinés à utiliser ces composés pour traiter des affections associées à la vitamine D3 ainsi que des compositions pharmaceutiques contenant lesdits composés.
Adorini Luciano
Colli Enrico
Marczak Stanislaw
Penna Guiseppe
Uskokovic Milan R.
Bioxell S.p.a.
Gowling Lafleur Henderson Llp
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