A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/20 (2006.01) A61K 31/00 (2006.01) A61K 31/18 (2006.01) A61K 31/201 (2006.01) A61K 31/202 (2006.01)
Patent
CA 2320706
20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid, 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid and 20-,21-dimethyl 20-HETE. Preferable 20-HETE antagonists include 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, 19-hydroxynonadeca-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid and 20-hydroxyeicosa 6(Z),15(Z)-dienoic acid.
L'invention concerne des agonistes et des antagonistes de 20-HETE, ainsi que leurs applications thérapeutiques. Dans une forme préférée de l'invention, les agonistes de HETE sont sélectionnés dans le groupe formé par un acide 21-hydroxyhénéicosa-5(Z),8(Z),11(Z),14(Z)-tétraénoïque, un acide 20-hydroxyéicosa-5(Z),14(Z)-diénoïque et 20-,21-diméthyle 20-HETE. De préférence, les antagonistes de 20-HETE comprennent 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, un acide 19-hydroxynonadéca-5(Z),8(Z),11(Z),14(Z)-tétraénoïque et un acide 20-hydroxyéicosa 6(Z),15(Z)-diénoïque.
Alonso-Galicia Magdalena
Falck John R.
Harder David R.
Jacobs Elizabeth R.
Roman Richard J.
Board Of Regents The University Of Texas System
Borden Ladner Gervais Llp
Mcw Research Foundation Inc.
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