20-hydroxyeicosatetraenoic acid production inhibitors

Details 20-hydroxyeicosatetraenoic acid production inhibitors 20-hydroxyeicosatetraenoic acid production inhibitors

C - Chemistry, Metallurgy

07

D

C07D 295/135 (2006.01) A61K 31/136 (2006.01) A61K 31/402 (2006.01) A61K 31/4418 (2006.01) A61K 31/451 (2006.01) A61K 31/4525 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/5375 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07C 259/14 (2006.01) C07D 207/20 (2006.01) C07D 211/22 (2006.01) C07D 211/46 (2006.01) C07D 211/60 (2006.01) C07D 211/70 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 215/06 (2006.01) C07D 217/04 (2006.01) C07D 223/04 (2006.01) C07D

Patent

CA 2445329

A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof. (see above formula) [wherein R1 represents a substituted morpholino group, a substituted piperidino group, a piperazin-1-yl group, a substituted piperazin-1-yl group, a thiomorpholin-1-yl group, a perhydroazepin-1-yl group, a perhydroazocin-1-yl group, a tetrahydropyridin-1-yl group, a pyrrolin-1-yl group, etc.; X represents a nitrogen atom or a group represented by CR5; and R2 to R5 are the same or different and each represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, a trifluoromethyl group or a halogen atom.] There is provided a drug which inhibits an enzyme producing 20-HETE participating in a contracting or dilating action for microvessels and an inducing action for cell proliferation in main organs such as kidney and cerebrovascular vessels.

L'invention concerne des composés d'hydroxyformamidine représentés par la formule générale ou des sels correspondants acceptables pharmaceutiquement. Dans cette formule, R<1> représente de la morpholine substituée, de la piperidine substituée, piperazine-1-yl, piperazine-1-yl substituée, thiomorpholine-1-yl, perhydroazépine-1-yl, perhydroazocine-1-yl, tétrahydropyridine-1-yl, pyrroline-1-yl, etc., X représente l'azote ou CR<5>, et R<2> à R<5> sont identiques ou différents et chacun d'eux représente l'hydrogène, C1-4 alkyle, C1-4 alkoxy, le trifluorométhyle ou l'halogène. Cette invention a aussi trait à des médicaments inhibant la 20-HETE synthase afférente à la contraction/dilatation de microvaisseaux, à l'induction de la prolifération cellulaire, etc., dans les organes essentiels, tels que les reins et les vaisseaux cérébraux.

Affiliated with

Also associated with

Rating

20-hydroxyeicosatetraenoic acid production inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 20-hydroxyeicosatetraenoic acid production inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 20-hydroxyeicosatetraenoic acid production inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1431439