C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/235.01
C07D 307/935 (2006.01) C07D 307/937 (2006.01)
Patent
CA 1183531
ABSTRACT OF THE DISCLOSURE This invention relates to a process for the preparation of a compound of formula (I) Image (I) where R is hydrogen or methyl and M is hydrogen or a pharmaceutically acceptable cation, characterized by subjecting to dehydrohalogenation dihalo compounds of formula (II) Image (II) where R and M have the meanings given in claim I and each of the groups XI and X2, which may be the same or different, is a halogen atom chosen from the bromine, chlorine and iodine group, and where a salt is required heating a compound of formula I with a base. The compounds of the invention are characterized by predominance of this disaggregating activity simultaneously with tha ability to relax the coronary arteries, and both these activities are at a higher level compared to PGI2 or its 20-methyl analogue. Moreover, like prostacyclin and 20-methyl prostacyclin, the compounds of the invention are totally free from prostaglandin-like activity and thromboxane-like activity; that is to say, they possess pure PGI2-like activity.
332125
Andreoni Alessandro
Ceserani Roberto
Gandolfi Carmelo
Farmitalia Carlo Erba S.p.a.
Fetherstonhaugh & Co.
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