20-spiroxanes and analogues having an open ring e, processes...

Details 20-spiroxanes and analogues having an open ring e, processes... 20-spiroxanes and analogues having an open ring e, processes...

C - Chemistry, Metallurgy

07

J

260/14

C07J 71/00 (2006.01) C07J 1/00 (2006.01) C07J 5/00 (2006.01) C07J 13/00 (2006.01) C07J 21/00 (2006.01) C07J 41/00 (2006.01) C07J 53/00 (2006.01)

Patent

CA 1220781

4-14388/+ 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof. Abstract Steroid compounds of the 20-spiroxane series and their analogues having an open ring E of the formula, Image (I) in which -A-A- represents the group -CH2-CH2- or -CH=CH-, R1 represents hydrogen, and R2 represents an .alpha.-oriented lower alkoxycarbonyl radical, or R1 and R2 together represent an .alpha.- or a .beta.-oriented methylene radical, -B-B- represents the group -CH2-CH2- or an .alpha.- or .beta.-oriented group Image , X represents two hydrogen atoms or oxo, Y1 and Y2 together represent the oxygen bridge -O-, or Y1 represents hydroxy, and Y represents hydroxy, lower alkoxy or, if X represents H2, also lower alkanoyloxy, and salts of compounds in which X represents oxo and Y represents hydroxy, are distinguished as effective aldosterone-antagonists with minimal side-effects and, for that reason, are especially suitable for the treatment of all forms of hyperaldosteronism.

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