C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61P 17/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2468833
This invention discloses (20S)-1.alpha.-hydroxy-2-methylene-19-nor- bishomopregnacalciferol, pharmaceutical uses therefor, and a method of purifying this compound to obtain it in crystalline form. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat immune disorders in humans as well as renal osteodystrophy.
La présente invention concerne le (20S)-1.alpha.-hydroxy-2-méthylène-19-nor-bishomoprégnacalciférol, ses utilisations pharmaceutiques et des procédés permettant de purifier ce composé pour l'obtenir sous forme cristalline. Ce composé fait preuve d'une activité notoire pour le blocage de la prolifération des cellules indifférentiées et pour l'induction de leur différentiation en monocyte, ce qui le destine à une utilisation comme anti-cancéreux et au traitement d'affections dermatologiques telles que le psoriasis et certains états de la peau: rides, peau flasque, peau sèche, et sécrétion insuffisante de sébum. Ce composé, qui ne présente pas ou très peu d'activité calcémique, convient particulièrement au traitement de troubles immunitaires humains, et de l'ostéodystrophie rénale.
Clagett-Dame Margaret
Deluca Hector F.
Gowlugari Sumithra
Grzywacz Pawel
Holden Hazel M.
Borden Ladner Gervais Llp
Wisconsin Alumni Research Foundation
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